Cobalt-chromium-molybdenum (CoCrMo) alloys are common biomaterials for orthopedic implants because of their biocompatibility and resistance to wear and corrosion. We are studying the effects of different heat treatments on the microstructures of the CoCrMo alloys and performing long-duration wear tests with conditions that mimic those of a prosthetic joint implant, including dynamic loading cycles and bovine serum lubrication. We also monitor the corrosion activity and any changes in microstructure throughout the wear tests. We aim to identify the material processing techniques that will maximize the wear and corrosion resistance of the CoCrMo biomaterials.